{"id":236696,"date":"2021-03-05T08:40:30","date_gmt":"2021-03-05T13:40:30","guid":{"rendered":"https:\/\/ziliahealth.com\/blog\/5-best-reads-in-ocular-oximetry\/"},"modified":"2021-03-05T09:56:10","modified_gmt":"2021-03-05T14:56:10","slug":"5-meilleures-lectures-en-oxymetrie-oculaire","status":"publish","type":"post","link":"https:\/\/ziliahealth.com\/fr\/blog\/5-meilleures-lectures-en-oxymetrie-oculaire\/","title":{"rendered":"5 meilleures lectures en oxym\u00e9trie oculaire"},"content":{"rendered":"

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Vous avez entendu parler de l\u2019oxym\u00e9trie oculaire et vous \u00eates curieux d\u2019en apprendre davantage sur ses impacts cliniques potentielles? Plut\u00f4t que de passer au crible les divers bases de donn\u00e9es et les moteurs de recherche, nous avons fait le gros du travail pour vous et vous pr\u00e9sentons ici cinq des meilleurs articles sur le sujet.<\/span><\/p>\n

[\/et_pb_cta][et_pb_image src=\u00a0\u00bbhttps:\/\/ziliahealth.com\/wp-content\/uploads\/2021\/03\/5_best_reads_in_retinal_oximetry.jpg\u00a0\u00bb alt=\u00a0\u00bb5_best_reads_in_retinal_oximetry\u00a0\u00bb _builder_version=\u00a0\u00bb4.9.1″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb55.25em\u00a0\u00bb custom_margin=\u00a0\u00bb|auto||auto|false|false\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb _builder_version=\u00a0\u00bb4.6.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb\u00a0\u00bb da_disable_devices=\u00a0\u00bboff|off|off\u00a0\u00bb da_is_popup=\u00a0\u00bboff\u00a0\u00bb da_exit_intent=\u00a0\u00bboff\u00a0\u00bb da_has_close=\u00a0\u00bbon\u00a0\u00bb da_alt_close=\u00a0\u00bboff\u00a0\u00bb da_dark_close=\u00a0\u00bboff\u00a0\u00bb da_not_modal=\u00a0\u00bbon\u00a0\u00bb da_is_singular=\u00a0\u00bboff\u00a0\u00bb da_with_loader=\u00a0\u00bboff\u00a0\u00bb da_has_shadow=\u00a0\u00bbon\u00a0\u00bb][et_pb_row custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb _builder_version=\u00a0\u00bb4.6.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb0px||0px||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.6.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.9.1″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb7vh||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb7vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb6vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||30px||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]<\/p>\n

Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases (1)<\/h3>\n

Dans cette \u00e9tude, l\u2019oxym\u00e9trie r\u00e9tinienne est \u00e9tudi\u00e9e en tant que m\u00e9thode non invasive pouvant permettre le diagnostic pr\u00e9coce et la stadification de plusieurs maladies oculaires telles la r\u00e9tinopathie diab\u00e9tique (RD), l\u2019occlusion veineuse centrale de la r\u00e9tine (OVCR), la r\u00e9tinite pigmentaire, le glaucome, ainsi que de maladies neurologiques telles la maladie d\u2019Alzheimer et la scl\u00e9rose en plaques.<\/p>\n

La RD et l\u2019OVCR sont des affections marqu\u00e9es par l\u2019hypoxie r\u00e9tinienne. En examinant l\u2019oxym\u00e9trie dans la r\u00e9tinopathie diab\u00e9tique, les auteurs ont constat\u00e9 une augmentation de la saturation veineuse en oxyg\u00e8ne et une diminution de la diff\u00e9rence art\u00e9rioveineuse. Dans les deux cas, il y a une perturbation du flux sanguin avec une hypoxie tissulaire r\u00e9sultante ainsi qu\u2019une production de facteur de croissance de l\u2019endoth\u00e9lium vasculaire (VEGF). Ces deux aspects physiopathologiques entra\u00eenent des modifications de la saturation en oxyg\u00e8ne. Pour ces deux conditions, il existe \u00e9galement une corr\u00e9lation entre la gravit\u00e9 de la maladie et le niveau d\u2019hypoxie.<\/p>\n

Les auteurs proposent la r\u00e9tinite pigmentaire et le glaucome comme deux affections atrophiques puisque la consommation d\u2019oxyg\u00e8ne est r\u00e9duite et en corr\u00e9lation avec l\u2019atrophie et la r\u00e9duction du champ visuel.<\/p>\n

Finalement, la r\u00e9tine \u00e9tant une extension du cerveau, il n\u2019est pas surprenant que l\u2019oxym\u00e9trie oculaire soit \u00e9galement alt\u00e9r\u00e9e chez les patients atteints de la maladie d\u2019Alzheimer et de la scl\u00e9rose en plaques. Si le potentiel de l’oxym\u00e9trie r\u00e9tinienne est prometteur, les auteurs concluent qu’il est n\u00e9cessaire d’\u00e9tendre le nombre d’\u00e9tudes prospectives dans ce domaine.<\/p>\n

Retinal oximetry in patients with ischaemic retinal diseases (2)<\/h3>\n

Cette revue de litt\u00e9rature s\u2019est pench\u00e9e sur les associations entre la saturation en oxyg\u00e8ne et les maladies isch\u00e9miques de la r\u00e9tine. Les auteurs ont choisi 10 publications d\u2019int\u00e9r\u00eat sur le sujet : 6 portant sur la DR et 4 sur l\u2019OVCR. En ce qui concerne le diab\u00e8te, les six \u00e9tudes ont r\u00e9v\u00e9l\u00e9 une association entre l\u2019augmentation de la saturation en oxyg\u00e8ne dans les veines de la r\u00e9tine et la pr\u00e9sence de RD. Elles ont \u00e9galement constat\u00e9 une corr\u00e9lation entre le niveau de saturation des veines de la r\u00e9tine et la gravit\u00e9 de la RD. La plupart des \u00e9tudes, 4 sur 6, ont \u00e9galement constat\u00e9 une augmentation de la saturation art\u00e9rielle en oxyg\u00e8ne de la r\u00e9tine en RD. Dans le cas de l\u2019OVCR, toutes les \u00e9tudes ont constat\u00e9 une augmentation de la saturation en oxyg\u00e8ne des veines de la r\u00e9tine, mais pas des art\u00e8res.<\/p>\n

Cet article a examin\u00e9 les \u00e9tudes utilisant des appareils d\u2019oxym\u00e9trie \u00e0 deux longueurs d\u2019onde. Leur nombre est limit\u00e9 par le fait que l\u2019oxym\u00e9trie oculaire est encore une discipline relativement nouvelle. En outre, la seule litt\u00e9rature disponible porte sur des \u00e9tudes transversales ou des s\u00e9ries de cas\u2009; il n\u2019y pas encore eu d\u2019\u00e9tudes prospectives ou d\u2019essais cliniques sur le sujet. N\u00e9anmoins, le fait qu\u2019il existe des marqueurs mesurables et pr\u00e9visibles de la saturation en oxyg\u00e8ne dans ces conditions est prometteur quant \u00e0 l\u2019usage de l\u2019oxym\u00e9trie oculaire dans la gestion des maladies oculaires.<\/p>\n

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L\u2019oxym\u00e9trie oculaire r\u00e9v\u00e8lerait m\u00eame les effets de l\u2019hypoxie dans des conditions syst\u00e9miques telles que les maladies cardiaques et pulmonaires.<\/p>\n<\/blockquote>\n

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Retinal oximetry: Metabolic imaging for diseases of the retina and brain (3)<\/h3>\n

Cette \u00e9tude corrobore l\u2019utilit\u00e9 de l\u2019oxym\u00e9trie oculaire dans les maladies de la r\u00e9tine et du cerveau.<\/p>\n

R\u00e9tinopathie diab\u00e9tique (RD)<\/h4>\n

Dans la RD, la saturation en oxyg\u00e8ne des veines de la r\u00e9tine est \u00e9lev\u00e9e et la diff\u00e9rence art\u00e9rioveineuse s\u2019amenuise \u00e0 mesure que la condition progresse. Ceci pourrait s\u2019expliquer par la production de VEGF suivant l\u2019hypoxie. L\u2019article relate \u00e9galement que des interventions th\u00e9rapeutiques telles que le traitement au laser et la vitrectomie semblent am\u00e9liorer l\u2019oxyg\u00e9nation r\u00e9tinienne.<\/p>\n

Occlusion de la veine centrale de la r\u00e9tine (OVCR)<\/h4>\n

La gravit\u00e9 de l\u2019OVCR serait corr\u00e9l\u00e9e avec les r\u00e9sultats de l\u2019oxym\u00e9trie oculaire. Plus pr\u00e9cis\u00e9ment, une isch\u00e9mie p\u00e9riph\u00e9rique accrue, une perte d\u2019acuit\u00e9 visuelle et une augmentation de l\u2019\u00e9paisseur de l\u2019\u0153d\u00e8me maculaire seraient associ\u00e9es \u00e0 une plus faible saturation en oxyg\u00e8ne au niveau des veinules r\u00e9tiniennes.<\/p>\n

Glaucome et r\u00e9tinite pigmentaire<\/h4>\n

Dans ces deux maladies, l\u2019atrophie de la r\u00e9tine serait associ\u00e9e \u00e0 une consommation r\u00e9duite en oxyg\u00e8ne. Il en r\u00e9sulterait une plus grande saturation veineuse et une r\u00e9duction de la diff\u00e9rence art\u00e9rioveineuse. Dans le glaucome, des valeurs d\u2019oxym\u00e9trie oculaire plus basses seraient observ\u00e9es avec des anneaux neuro-r\u00e9tiniens plus fins, des champs visuels restreints et une r\u00e9duction de l\u2019\u00e9paisseur de la couche des fibres nerveuses. De m\u00eame, dans la r\u00e9tinite pigmentaire, la saturation r\u00e9tinienne en oxyg\u00e8ne serait affect\u00e9e lors d\u2019une atrophie avanc\u00e9e et une d\u00e9t\u00e9rioration du champ visuel.<\/p>\n

Maladie syst\u00e9mique<\/h4>\n

L\u2019oxym\u00e9trie oculaire r\u00e9v\u00e8lerait m\u00eame les effets de l\u2019hypoxie dans des conditions syst\u00e9miques telles que les maladies cardiaques et pulmonaires. Des affections neurologiques telles que la maladie d\u2019Alzheimer et la scl\u00e9rose en plaques ont \u00e9galement montr\u00e9 une corr\u00e9lation avec les valeurs de l\u2019oxym\u00e9trie oculaire.<\/p>\n

Retinal oximetry in glaucoma: investigations and findings reviewed (4)<\/h3>\n

Nous savons depuis longtemps que des facteurs autres que la pression intraoculaire jouent un r\u00f4le dans la physiopathologie du glaucome. \u00c0 ce titre, la perturbation du flux sanguin au niveau du nerf optique serait un facteur de risque important de la maladie.<\/p>\n

Cet article avance l\u2019hypoth\u00e8se qu\u2019il pourrait y avoir deux fa\u00e7ons dont la circulation sanguine serait impliqu\u00e9e dans le glaucome. L\u2019hypoth\u00e8se vasculaire sugg\u00e8re que l\u2019alt\u00e9ration de la circulation sanguine serait fondamentale, entra\u00eenant une atrophie des tissus. L\u2019hypoth\u00e8se m\u00e9canique quant \u00e0 elle, propose que des facteurs non vasculaires, tels qu\u2019une pression intraoculaire accrue, provoqueraient une atrophie des tissus. La demande en oxyg\u00e8ne diminuerait subs\u00e9quemment.<\/p>\n

L\u2019oxym\u00e9trie oculaire pourrait jouer un r\u00f4le dans l\u2019\u00e9tude de ces deux hypoth\u00e8ses non mutuellement exclusives. Les mod\u00e8les math\u00e9matiques sugg\u00e8rent que l\u2019hypoth\u00e8se m\u00e9canique peut \u00eatre pr\u00e9dominante dans la physiopathologie du glaucome \u00e0 haute tension, tandis que l\u2019hypoth\u00e8se vasculaire peut mieux expliquer le glaucome normotensif. La poursuite des recherches dans ce domaine pourrait aider \u00e0 identifier de nouvelles cibles th\u00e9rapeutiques afin d\u2019am\u00e9liorer les r\u00e9sultats pour les patients.<\/p>\n

Convolutional Neural Networks for Spectroscopic Analysis in Retinal Oximetry (5)<\/h3>\n

Cet article vise \u00e0 rem\u00e9dier aux incoh\u00e9rences quantitatives des mesures d\u2019oxym\u00e9trie oculaire, qui ont jusqu\u2019\u00e0 pr\u00e9sent limit\u00e9 la port\u00e9e clinique de cette technologie. Les auteurs ont d\u00e9velopp\u00e9 un algorithme de r\u00e9seau neuronal convolutif (CNN) pour l\u2019oxym\u00e9trie multi-longueurs d\u2019onde. Cette technique sans \u00e9talonnage d\u00e9montre la capacit\u00e9 \u00e0 d\u00e9tecter les quatre diff\u00e9rentes conformations de l\u2019h\u00e9moglobine et \u00e0 d\u00e9duire efficacement l\u2019oxyg\u00e9nation effective et l\u2019oxyg\u00e9nation fractionn\u00e9e.<\/p>\n

Cette m\u00e9thode s\u2019attaque \u00e0 trois limitations qui ont historiquement affect\u00e9 la mesure de l\u2019oxym\u00e9trie oculaire. Premi\u00e8rement, les algorithmes utilis\u00e9s dans les syst\u00e8mes \u00e0 deux ou trois longueurs d\u2019onde sont sensibles \u00e0 la diffusion et \u00e0 l\u2019absorption dans l\u2019\u0153il. Deuxi\u00e8mement, les syst\u00e8mes actuels souffrent souvent d\u2019un mauvais \u00e9talonnage spectral. Troisi\u00e8mement, l\u2019oxym\u00e9trie oculaire s\u2019est historiquement concentr\u00e9e sur la saturation en oxyg\u00e8ne effective, tandis que la saturation en oxyg\u00e8ne fractionn\u00e9e est plus pertinente sur le plan clinique. Cette derni\u00e8re prend en compte les dysh\u00e9moglobines, qui peuvent affecter la quantit\u00e9 d\u2019oxyg\u00e8ne circulant. L\u2019algorithme CNN propos\u00e9, en raison de sa pr\u00e9cision et de sa r\u00e9p\u00e9tabilit\u00e9, s\u2019av\u00e8re prometteur pour la p\u00e9n\u00e9tration clinique de l\u2019oxym\u00e9trie oculaire.<\/p>\n

Conclusion<\/h3>\n

Et voil\u00e0, les cinq meilleures lectures en oxym\u00e9trie oculaire. En bref, l\u2019oxym\u00e9trie oculaire est une technologie prometteuse qui pourrait permettre de diagnostiquer plus t\u00f4t et de mieux prendre en charge de nombreuses maladies oculaires, neurologiques et m\u00eame syst\u00e9miques. Des travaux suppl\u00e9mentaires sont n\u00e9cessaires pour am\u00e9liorer l\u2019exactitude et la pr\u00e9cision de ces mesures. \u00c0 cet \u00e9gard, la nouvelle technologie de Zilia, Zilia Ocular, actuellement en cours de d\u00e9veloppement s\u2019av\u00e8re prometteuse. Cette technologie innovante implique l\u2019utilisation de plusieurs longueurs d\u2019onde pour obtenir des mesures absolues et continues d\u2019oxym\u00e9trie, ouvrant la voie \u00e0 une foule d\u2019informations m\u00e9taboliques. Cela contribuera certainement \u00e0 faire avancer la recherche dans ce domaine et \u00e0 contribuer \u00e0 prot\u00e9ger la vue de nombreux patients.<\/p>\n

<\/h3>\n

<\/h3>\n

R\u00e9f\u00e9rences<\/h3>\n
    \n
  1. Einar Stef\u00e1nsson, Olof Birna Olafsdottir, Anna Bryndis Einarsdottir, Thorunn Scheving Eliasdottir, Thor Eysteinsson, Wouter Vehmeijer, Evelien Vandewalle, Toke Bek, Sveinn Hakon Hardarson; Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases. Invest. Ophthalmol. Vis. Sci. 2017;58(6):BIO227-BIO233. https:\/\/doi.org\/10.1167\/iovs.17-21776<\/a>.<\/li>\n
  2. Rilv\u00e9n, S., Torp, T.L. and Grauslund, J. Retinal oximetry in patients with ischaemic retinal diseases. Acta Ophthalmol. 2017;95:119-127. https:\/\/doi.org\/10.1111\/aos.13229<\/a><\/li>\n
  3. Stef\u00e1nsson, E., Olafsdottir, O., Eliasdottir, T.S., Vehmeijer, W.B., & Hardarson, S. Retinal oximetry: Metabolic imaging for diseases of the retina and brain. Progress in Retinal and Eye Research. 2019;70:1-22.https:\/\/doi.org\/10.1016\/j.preteyeres.2019.04.001<\/a>.<\/li>\n
  4. Shughoury A, Mathew S, Arciero J, Wurster P, Adjei S, Ciulla T, Siesky B, Harris A. Retinal oximetry in glaucoma: investigations and findings reviewed. Acta Ophthalmol. 2020 Sep;98(6):559-571. https:\/\/doi.org\/10.1111\/aos.14397<\/a>.<\/li>\n
  5. DePaoli, D.T., Tossou, P., Parent, M. et al. Convolutional Neural Networks for Spectroscopic Analysis in Retinal Oximetry. Sci Rep. 2019; 9:11387. https:\/\/doi.org\/10.1038\/s41598-019-47621-7<\/a>.<\/li>\n<\/ol>\n

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    \u00c9crit par l’\u00e9quipe Zilia le 5 mars 2021<\/p>\n

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    Lecture additionnelle<\/h2>\n

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    EN<\/a><\/p>\n

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    Zilia Inc. \u00a9 2020 | Privacy<\/a><\/p>\n

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    Zilia Inc. \u00a9 2020 <\/p>\n

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    Zilia Inc. \u00a9 2021<\/p>\n

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    L’oxym\u00e9trie oculaire est la mesure de la saturation en oxyg\u00e8ne du sang (StO\u2082) dans l’\u0153il. 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