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Le terme \u00ab\u00a0intelligence artificielle\u00a0\u00bb (IA) a \u00e9t\u00e9 invent\u00e9 en 1956 par John McCarthy qui a d\u00e9fini le concept comme \u00ab\u00a0science et l’ing\u00e9nierie permettant de fabriquer des machines intelligentes\u00a0\u00bb. (1)<\/p>\n
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Depuis lors, et plus particuli\u00e8rement au cours de la derni\u00e8re d\u00e9cennie, des progr\u00e8s importants ont conduit \u00e0 diverses r\u00e9alisations, notamment la reconnaissance des visages, le traitement du langage naturel, la reconnaissance vocale, la production de textes, la traduction de langues, etc. (2) Cependant, les d\u00e9veloppements les plus importants ont \u00e9t\u00e9 r\u00e9alis\u00e9s dans le domaine de la sant\u00e9 avec l\u2019objectif d\u2019acc\u00e9l\u00e9rer les processus, d\u2019augmenter la pr\u00e9cision, et ultimement, d\u2019am\u00e9liorer la sant\u00e9 globale des patients. (3)<\/p>\n
Afin d\u2019avoir un impact r\u00e9el sur les soins de sant\u00e9, l’IA et l’apprentissage machine (AM) doivent permettre d’identifier de nouvelles fa\u00e7ons pour le praticien de poser un diagnostic et d’\u00e9tablir des corr\u00e9lations insoup\u00e7onn\u00e9es. Pour ce faire, les algorithmes s’appuient sur l’extraction et l’analyse des donn\u00e9es de biomarqueurs. Les biomarqueurs, ou marqueurs biologiques, sont des indications objectives d’un \u00e9tat m\u00e9dical (par opposition aux sympt\u00f4mes rapport\u00e9s par le patient) qui peuvent \u00eatre mesur\u00e9es et reproduites avec pr\u00e9cision. (4) Les biomarqueurs permettent de mieux comprendre le fonctionnement du corps humain, notamment avec des applications dans la stratification du risque, le diagnostic, le pronostic et le suivi th\u00e9rapeutique.<\/p>\n
L’\u0153il est un endroit id\u00e9al pour identifier, valider et exploiter les biomarqueurs en raison de ses propri\u00e9t\u00e9s transparentes permettant un acc\u00e8s non invasif aux diff\u00e9rentes structures cl\u00e9s li\u00e9es \u00e0 la sant\u00e9 oculaire, c\u00e9r\u00e9brale et syst\u00e9mique.<\/p>\n
Depuis l’invention de l’ophtalmoscope en 1851, les m\u00e9decins sont en mesure d\u2019observer l’int\u00e9rieur de l’\u0153il. (7) \u00c0 travers la pupille, un clinicien peut voir directement, entre autres, les vaisseaux sanguins et le nerf optique, une extension directe du cerveau. Pour \u00e9valuer ces structures, la photographie du fond d’\u0153il est rapidement devenue une pratique standard dans le domaine des soins oculaires et un important g\u00e9n\u00e9rateur de donn\u00e9es de sant\u00e9. Avec les balises appropri\u00e9es du clinicien, l’IA et le AM visent \u00e0 faciliter le diagnostic des maladies oculaires courantes et \u00e0 accro\u00eetre l’\u00e9tendue des informations cliniques que nous pouvons obtenir \u00e0 partir de l’imagerie conventionnelle du fond d’\u0153il. Par exemple, l’analyse des images du fond d’\u0153il aliment\u00e9e par l’IA peut rep\u00e9rer une r\u00e9tinopathie diab\u00e9tique pr\u00e9coce chez des patients asymptomatiques et a \u00e9galement r\u00e9ussi \u00e0 d\u00e9tecter d’autres affections oculaires telles que la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge, le glaucome et la r\u00e9tinopathie des pr\u00e9matur\u00e9s. En 2018, la FDA a autoris\u00e9 IDx-DR, le premier syst\u00e8me qui utilise l’intelligence artificielle (IA) pour d\u00e9tecter une r\u00e9tinopathie diab\u00e9tique (RD) \u00ab\u00a0plus que l\u00e9g\u00e8re\u00a0\u00bb chez les adultes diab\u00e9tiques. Dans une \u00e9tude, IDx-DR a correctement identifi\u00e9 la pr\u00e9sence d’une r\u00e9tinopathie diab\u00e9tique plus que l\u00e9g\u00e8re dans 87,4 % des cas et a correctement identifi\u00e9 ceux qui ne pr\u00e9sentaient pas de r\u00e9tinopathie diab\u00e9tique plus que l\u00e9g\u00e8re dans 89,5 % des cas. (4) Des mod\u00e8les d’apprentissage profond ont \u00e9galement \u00e9t\u00e9 capables d’analyser les donn\u00e9es de la photographie du fond d’\u0153il de 284 335 patients et de pr\u00e9dire les facteurs de risque cardiovasculaire tels que l’\u00e2ge, le sexe, le tabagisme, la pression art\u00e9rielle systolique et les principaux \u00e9v\u00e9nements cardiaques ind\u00e9sirables. Les mod\u00e8les ont utilis\u00e9 des caract\u00e9ristiques anatomiques, telles que le disque optique ou les vaisseaux sanguins, pour g\u00e9n\u00e9rer des pr\u00e9dictions. (13)<\/p>\n
Ayant un lien direct avec le cerveau, l’\u0153il est souvent utilis\u00e9 comme une entr\u00e9e non invasive pour l’\u00e9tude et l’analyse des biomarqueurs neurologiques. Plusieurs \u00e9tudes utilisant l’analyse des mouvements oculaires (9) soulignent le potentiel de l\u2019AM pour pr\u00e9dire le comportement, les \u00e9tats cognitifs et les traits de personnalit\u00e9. (8) L’IA peut tirer des conclusions sur les traits de personnalit\u00e9 d’une personne (8) et m\u00eame d\u00e9tecter si elle ment en analysant les mouvements oculaires (12). Des caract\u00e9ristiques informatives peuvent \u00eatre d\u00e9termin\u00e9es automatiquement \u00e0 partir d’un ensemble vaste et diversifi\u00e9 de caract\u00e9ristiques et de mod\u00e8les de mouvements oculaires, ce qui permet de d\u00e9couvrir des liens jusqu’alors inconnus entre la personnalit\u00e9 et le regard. En utilisant l’AM et un ensemble de caract\u00e9ristiques des mouvements oculaires, un logiciel a pu pr\u00e9dire de mani\u00e8re fiable quatre des cinq grands traits de personnalit\u00e9 (n\u00e9vrosisme, extraversion, amabilit\u00e9, conscience) ainsi que la curiosit\u00e9 perceptive. (8) Les mouvements oculaires peuvent \u00e9galement \u00eatre utilis\u00e9s pour suivre l’\u00e9volution de la maladie et l’efficacit\u00e9 des traitements dans les troubles c\u00e9r\u00e9braux comme l’autisme, la maladie d’Alzheimer, la schizophr\u00e9nie, la n\u00e9gligence et la scl\u00e9rose en plaques. (10) Pour cette derni\u00e8re maladie, la FDA a tout r\u00e9cemment accord\u00e9 la d\u00e9signation de \u00ab\u00a0Breakthrough Device\u00a0\u00bb \u00e0 Innodem Neurosciences pour son dispositif ETNA\u2122 destin\u00e9 \u00e0 enregistrer les mouvements oculaires pour les utiliser dans l’estimation de la gravit\u00e9 de la maladie chez les patients atteints de scl\u00e9rose en plaques. (21) <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bbrgba(135,210,150,0.26)\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb30px||30px||false|false\u00a0\u00bb border_color_all=\u00a0\u00bb#87d296″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb|20px||20px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb|20px||20px|false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.17.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbMontserrat Regular|500|||||||\u00a0\u00bb text_line_height=\u00a0\u00bb1.25em\u00a0\u00bb quote_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb quote_text_align=\u00a0\u00bbleft\u00a0\u00bb quote_font_size=\u00a0\u00bb2rem\u00a0\u00bb quote_line_height=\u00a0\u00bb1.4em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb\u00a0\u00bb text_line_height_phone=\u00a0\u00bb1.28em\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb quote_font_size_tablet=\u00a0\u00bb1.5rem\u00a0\u00bb quote_font_size_phone=\u00a0\u00bb1.4rem\u00a0\u00bb quote_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb quote_line_height_tablet=\u00a0\u00bb\u00a0\u00bb quote_line_height_phone=\u00a0\u00bb\u00a0\u00bb quote_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
La collecte de donn\u00e9es dans l’\u0153il a souvent \u00e9t\u00e9 limit\u00e9e \u00e0 l’imagerie. L’utilisation de la spectrom\u00e9trie par r\u00e9flectance diffuse (SRD) peut amener la collecte de donn\u00e9es dans l’\u0153il \u00e0 un tout autre niveau.<\/p><\/blockquote>\n
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L’utilisation de la spectroscopie dans les soins oculaires<\/h3>\n
La collecte de donn\u00e9es dans l’\u0153il a souvent \u00e9t\u00e9 limit\u00e9e \u00e0 l’imagerie. L’utilisation de la spectrom\u00e9trie par r\u00e9flectance diffuse (SRD) peut amener la collecte de donn\u00e9es dans l’\u0153il \u00e0 un tout autre niveau. En exploitant l’ensemble du spectre lumineux, il est d\u00e9sormais possible d’analyser les caract\u00e9ristiques optiques des tissus biologiques avec des niveaux de pr\u00e9cision sans pr\u00e9c\u00e9dent. (14) Cette technique est d\u00e9j\u00e0 largement utilis\u00e9e dans d’autres domaines de la m\u00e9decine, notamment la microbiologie et l’analyse pharmaceutique. (15) L’imagerie spectrale \u00e9tend les capacit\u00e9s en combinant la spectroscopie et l’imagerie, fournissant \u00e0 la fois des informations spectrales et structurelles. (16)<\/p>\n
Une application prometteuse de la spectroscopie dans l’\u0153il est l’oxym\u00e9trie oculaire. L’oxym\u00e9trie oculaire utilise l’analyse spectroscopique pour \u00e9tudier l’h\u00e9modynamique de l’\u0153il. Plus pr\u00e9cis\u00e9ment, il s’agit d’une technique directe et non invasive qui \u00e9value la saturation en oxyg\u00e8ne des tissus de la r\u00e9tine. L’h\u00e9moglobine, une prot\u00e9ine pr\u00e9sente dans les globules rouges, transporte l’oxyg\u00e8ne du sang vers les tissus. L’oxym\u00e9trie r\u00e9tinienne analyse les profils spectraux distincts de l’h\u00e9moglobine oxyg\u00e9n\u00e9e et d\u00e9soxyg\u00e9n\u00e9e pour d\u00e9terminer la saturation en oxyg\u00e8ne. (17)<\/p>\n
Les donn\u00e9es des \u00e9tudes tendent \u00e0 indiquer que la saturation en oxyg\u00e8ne de la r\u00e9tine est alt\u00e9r\u00e9e dans une grande vari\u00e9t\u00e9 de maladies oculaires et syst\u00e9miques. Par exemple, les anomalies de l’approvisionnement en sang de la r\u00e9tine ont \u00e9t\u00e9 impliqu\u00e9es dans le glaucome primaire \u00e0 angle ouvert, la r\u00e9tinopathie diab\u00e9tique, la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge ainsi que l’occlusion des art\u00e8res et des veines. (20)<\/p>\n
Conclusion<\/h3>\n
En utilisant l’\u0153il comme une fen\u00eatre, les biomarqueurs aliment\u00e9s par l’IA g\u00e9n\u00e8rent une foule d’informations avec un v\u00e9ritable potentiel pour changer la fa\u00e7on dont nous g\u00e9rons le diagnostic et le suivi de multiples maladies. La convergence du big data, de l’IA et de l’\u00e9tude des biomarqueurs oculaires a un \u00e9norme potentiel de fournir l’\u00e9valuation la plus compl\u00e8te et la plus avanc\u00e9e de la sant\u00e9 oculaire, neurologique et syst\u00e9mique, permettant une d\u00e9tection pr\u00e9coce et une meilleure gestion de diverses maladies.<\/p>\n
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(16) Mordant, D., Al-Abboud, I., Muyo, G.\u00a0et al.\u00a0Spectral imaging of the retina.\u00a0Eye\u00a025,\u00a0309\u2013320 (2011). https:\/\/doi.org\/10.1038\/eye.2010.222<\/span><\/p>\n
(17) Anupam K. Garg, Darren Knight, Leonardo Lando, Daniel L. Chao; Advances in retinal oximetry.\u00a0Trans. Vis. Sci. Tech.2021;10(2):5. doi:\u00a0https:\/\/doi.org\/10.1167\/tvst.10.2.5.<\/span><\/p>\n
(18) DePaoli, D.T., Tossou, P., Parent, M.\u00a0et al.\u00a0Convolutional neural networks for spectroscopic analysis in retinal oximetry.\u00a0Sci Rep\u00a09,\u00a011387 (2019). https:\/\/doi.org\/10.1038\/s41598-019-47621-7<\/span><\/p>\n
(19) Shughoury A, Mathew S, Arciero J, Wurster P, Adjei S, Ciulla T, Siesky B, Harris A. Retinal oximetry in glaucoma: investigations and findings reviewed. Acta Ophthalmol. 2020 Sep;98(6):559-571. doi: 10.1111\/aos.14397. Epub 2020 Apr 5. PMID: 32248646.<\/span><\/p>\n
(20) Balyen, Lokman MD<\/span>\u2217<\/span>; Peto, Tunde MD, PhD<\/span>\u2020<\/span>\u00a0Promising artificial intelligence-machine learning-deep learning algorithms in ophthalmology, Asia-Pacific Journal of Ophthalmology: May-June 2019 – Volume 8 – Issue 3 – p 264-272 doi: 10.22608\/APO.2018479<\/span><\/p>\n
(21) Newswire. Etna device from the leading digital health & AI company Innodem Neurosciences receives FDA \u201cBreakthrough\u201d designation for multiple sclerosis. https:\/\/www.newswire.ca\/news-releases\/etna-tm-device-from-the-leading-digital-health-amp-ai-company-innodem-neurosciences-receives-fda-breakthrough-designation-for-multiple-sclerosis-811734861.html Published May 31, 2022. Accessed June 13, 2022<\/span><\/p>\n
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Lecture additionnelle<\/h2>\n
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text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb]<\/p>\n
\u00c0 propos<\/p>\n
[\/et_pb_text][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.17.4″ text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Mission<\/a>
Blogue
<\/a>Nouvelles<\/a>
Carri\u00e8res<\/a>
\u00c9v\u00e8nements
<\/a>Contactez-nous<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″ _builder_version=\u00a0\u00bb4.16″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Solutions<\/p>\n
[\/et_pb_text][et_pb_text content_phone=\u00a0\u00bb<\/p>\n
Technology<\/a>
Zilia Ocular
<\/a>Vision Loss<\/a><\/p>\n\u00a0\u00bb content_last_edited=\u00a0\u00bboff|desktop\u00a0\u00bb disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Technologie<\/a>
Zilia Ocular
<\/a>Soins oculaires<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″ _builder_version=\u00a0\u00bb4.16″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]L\u00e9gal[\/et_pb_text][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Cookies<\/a>
Confidentialit\u00e9<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_3,1_3,1_3″ module_class=\u00a0\u00bbthree-columns\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb20px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb10px||14px||false|false\u00a0\u00bb custom_css_main_element=\u00a0\u00bbdisplay: flex;\u00a0\u00bb border_width_top=\u00a0\u00bb1px\u00a0\u00bb border_color_top=\u00a0\u00bb#c6c6c6″ border_color_bottom=\u00a0\u00bb#dddddd\u00a0\u00bb border_style_top_tablet=\u00a0\u00bb\u00a0\u00bb border_style_top_phone=\u00a0\u00bb\u00a0\u00bb border_style_top_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb custom_css_main_element_tablet=\u00a0\u00bbdisplay: flex;||flex-wrap: wrap;\u00a0\u00bb custom_css_main_element_phone=\u00a0\u00bbdisplay: flex;||flex-wrap: wrap;\u00a0\u00bb width__hover_enabled=\u00a0\u00bbon|desktop\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb transform_scale_tablet=\u00a0\u00bb\u00a0\u00bb transform_scale_phone=\u00a0\u00bb\u00a0\u00bb transform_scale_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_translate_tablet=\u00a0\u00bb\u00a0\u00bb transform_translate_phone=\u00a0\u00bb\u00a0\u00bb transform_translate_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb transform_translate_linked_tablet=\u00a0\u00bboff\u00a0\u00bb transform_rotate_tablet=\u00a0\u00bb\u00a0\u00bb transform_rotate_phone=\u00a0\u00bb\u00a0\u00bb transform_rotate_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb transform_skew_tablet=\u00a0\u00bb\u00a0\u00bb transform_skew_phone=\u00a0\u00bb\u00a0\u00bb transform_skew_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb transform_origin_tablet=\u00a0\u00bb\u00a0\u00bb transform_origin_phone=\u00a0\u00bb\u00a0\u00bb transform_origin_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb transform_styles_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_styles_tablet=\u00a0\u00bb\u00a0\u00bb transform_styles_phone=\u00a0\u00bb\u00a0\u00bb custom_css_main_element=\u00a0\u00bbmargin:auto\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb module_class=\u00a0\u00bbcopyright\u00a0\u00bb _builder_version=\u00a0\u00bb4.17.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb module_alignment=\u00a0\u00bbleft\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb\u00a0\u00bb custom_padding_phone=\u00a0\u00bb10px||||false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb link_option_url=\u00a0\u00bbhttp:\/\/ziliahealth.com\/fr\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb]<\/p>\n