{"id":239170,"date":"2025-11-12T13:04:02","date_gmt":"2025-11-12T18:04:02","guid":{"rendered":"https:\/\/ziliahealth.com\/blog\/the-eye-a-window-into-cardiovascular-health\/"},"modified":"2025-11-12T14:01:51","modified_gmt":"2025-11-12T19:01:51","slug":"oeil-fenetre-sante-cardiovasculaire","status":"publish","type":"post","link":"https:\/\/ziliahealth.com\/fr\/blog\/oeil-fenetre-sante-cardiovasculaire\/","title":{"rendered":"L\u2019\u0153il, fen\u00eatre sur la sant\u00e9 cardiovasculaire: ce que la r\u00e9tine r\u00e9v\u00e8le du c\u0153ur"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb4.19.0&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#f7f7f7&Prime; height=\u00a0\u00bb60vh\u00a0\u00bb height_tablet=\u00a0\u00bb80vh\u00a0\u00bb height_phone=\u00a0\u00bb70vh\u00a0\u00bb height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_css_main_element=\u00a0\u00bbposition: relative;\u00a0\u00bb da_disable_devices=\u00a0\u00bboff|off|off\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb da_is_popup=\u00a0\u00bboff\u00a0\u00bb da_exit_intent=\u00a0\u00bboff\u00a0\u00bb da_has_close=\u00a0\u00bbon\u00a0\u00bb da_alt_close=\u00a0\u00bboff\u00a0\u00bb da_dark_close=\u00a0\u00bboff\u00a0\u00bb da_not_modal=\u00a0\u00bbon\u00a0\u00bb da_is_singular=\u00a0\u00bboff\u00a0\u00bb da_with_loader=\u00a0\u00bboff\u00a0\u00bb da_has_shadow=\u00a0\u00bbon\u00a0\u00bb][et_pb_row custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb admin_label=\u00a0\u00bbCase Study Row\u00a0\u00bb _builder_version=\u00a0\u00bb4.19.0&Prime; 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_module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb0px||0px||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb1.6em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb5vh||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb7vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb6vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p><span style=\"font-weight: 400;\">La r\u00e9tine offre une vue unique et non invasive sur la microvascularisation de l\u2019organisme \u2014 ces minuscules art\u00e8res, veines et capillaires o\u00f9 les maladies syst\u00e9miques se manifestent souvent en premier.(<\/span><span style=\"font-weight: 400;\">1,2)<\/span><span style=\"font-weight: 400;\"> Les avanc\u00e9es en imagerie r\u00e9tinienne et en intelligence artificielle (IA) permettent maintenant aux cliniciens de d\u00e9tecter les maladies cardiovasculaires avant m\u00eame l\u2019apparition des sympt\u00f4mes, d\u2019identifier les facteurs de risque et de pr\u00e9dire des \u00e9v\u00e9nements graves tels que les crises cardiaques et les accidents vasculaires c\u00e9r\u00e9braux (AVC).(<\/span><span style=\"font-weight: 400;\">3)<\/span><span style=\"font-weight: 400;\"> Cette rencontre entre anatomie et technologie transformera peu \u00e0 peu les examens de la vue de routine en puissants outils de m\u00e9decine pr\u00e9ventive.(<\/span><span style=\"font-weight: 400;\">4)<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text ul_item_indent=\u00a0\u00bb40px\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb2em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb max_width_tablet=\u00a0\u00bb\u00a0\u00bb max_width_phone=\u00a0\u00bb\u00a0\u00bb max_width_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb1em||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb header_4_line_height_tablet=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_phone=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<h3>Le lien biologique: pourquoi la r\u00e9tine refl\u00e8te le c\u0153ur<\/h3>\n<p>Le lien entre la sant\u00e9 oculaire et cardiovasculaire repose sur une architecture vasculaire commune. La r\u00e9tine est le seul endroit du corps o\u00f9 l\u2019on peut observer directement, in vivo, les art\u00e8res, les veines et les capillaires.(5) Ces vaisseaux partagent des caract\u00e9ristiques structurelles et physiologiques avec ceux du c\u0153ur et du cerveau, faisant de l\u2019\u0153il un miroir naturel du syst\u00e8me vasculaire.(6)<\/p>\n<p>Les atteintes vasculaires \u2014 qu\u2019elles soient dues \u00e0 un dysfonctionnement endoth\u00e9lial, \u00e0 une contrainte de cisaillement alt\u00e9r\u00e9e par l\u2019hypertension, \u00e0 un d\u00e9couplage neurovasculaire li\u00e9 \u00e0 un d\u00e9s\u00e9quilibre en oxyg\u00e8ne ou encore au stress oxydatif induit par l\u2019isch\u00e9mie \u2014 apparaissent souvent d\u2019abord dans la r\u00e9tine.(2) C\u2019est ainsi qu\u2019est n\u00e9e l\u2019oculomique cardiovasculaire, une discipline qui \u00e9tudie les biomarqueurs oculaires refl\u00e9tant la sant\u00e9 du syst\u00e8me cardio-vasculaire.<\/p>\n<p>Quelques signes r\u00e9tiniens associ\u00e9s aux maladies cardiovasculaires:<\/p>\n<p><span style=\"font-weight: 400;\"><\/span><\/p>\n<ul>\n<li><strong>Art\u00e9rioles r\u00e9tr\u00e9cies et veinules dilat\u00e9es:<\/strong> signes classiques d\u2019hypertension et d\u2019insuffisance cardiaque.(7)<\/li>\n<li><strong>L\u00e9sions vasculaires:<\/strong> h\u00e9morragies r\u00e9tiniennes, microan\u00e9vrismes et exsudats cotonneux, indiquant des dommages vasculaires chroniques souvent li\u00e9s \u00e0 l\u2019hypertension ou au diab\u00e8te.(8)<\/li>\n<li><strong>Perfusion r\u00e9duite et rar\u00e9faction capillaire:<\/strong> baisse de la densit\u00e9 vasculaire t\u00e9moignant d\u2019un dysfonctionnement microvasculaire et d\u2019une sous-perfusion chronique.(9)<\/li>\n<li><strong>Vaisseaux tortueux:<\/strong> courbure accrue des art\u00e9rioles ou veinules, reflet d\u2019un remodelage vasculaire et d\u2019un stress h\u00e9modynamique associ\u00e9s \u00e0 l\u2019hypertension, \u00e0 l\u2019ath\u00e9roscl\u00e9rose et aux AVC.(10-11)<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text ul_item_indent=\u00a0\u00bb50px\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb2em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb max_width_tablet=\u00a0\u00bb\u00a0\u00bb max_width_phone=\u00a0\u00bb\u00a0\u00bb max_width_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb1em||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb header_4_line_height_tablet=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_phone=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<h3>De la structure au m\u00e9tabolisme : les progr\u00e8s technologiques<\/h3>\n<p><span style=\"font-weight: 400;\">L\u2019imagerie r\u00e9tinienne moderne permet aux cliniciens d\u2019aller bien au-del\u00e0 de la simple observation, en offrant des informations structurelles, circulatoires et, de plus en plus, fonctionnelles sur la sant\u00e9 vasculaire.<\/span><\/p>\n<h4>Visualisation de la structure et du flux sanguin<\/h4>\n<p>Chaque modalit\u00e9 d\u2019imagerie met en lumi\u00e8re un aspect particulier:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Photographie du fond d\u2019\u0153il:<\/strong> produit des images bidimensionnelles d\u00e9taill\u00e9es de la surface r\u00e9tinienne, r\u00e9v\u00e9lant des changements tels que les h\u00e9morragies, les exsudats cotonneux et le pincement art\u00e9rio-veineux \u2014 des signes typiques d\u2019hypertension chronique.(12)<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Tomographie par coh\u00e9rence optique (OCT)<\/strong>: fournit des images microscopiques en coupe des couches r\u00e9tiniennes, permettant de mesurer la couche des fibres nerveuses r\u00e9tiniennes et de d\u00e9tecter des l\u00e9sions isch\u00e9miques subtiles comme les l\u00e9sions p\u00e9rivasculaires isch\u00e9miques r\u00e9tiniennes (RIPL).(13,14)<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Angiographie par OCT (OCT-A)<\/strong>: cartographie le flux sanguin en suivant le mouvement des globules rouges sans recours \u00e0 un colorant. Elle fournit des mesures quantitatives comme la densit\u00e9 de surface des vaisseaux et la taille de la zone avasculaire fov\u00e9ale.(15)<\/li>\n<\/ul>\n<p>Malgr\u00e9 ces avanc\u00e9es, un \u00e9cart critique subsiste : ces outils ne d\u00e9tectent les changements structurels et circulatoires qu\u2019apr\u00e8s des alt\u00e9rations m\u00e9taboliques significatives. Autrement dit, la photographie du fond d\u2019\u0153il, l\u2019OCT et l\u2019OCT-A ne r\u00e9v\u00e8lent que la partie visible de l\u2019iceberg \u2014 les dommages d\u00e9j\u00e0 install\u00e9s. Pour passer d\u2019un diagnostic r\u00e9actif \u00e0 une approche pr\u00e9ventive, il faut des biomarqueurs fonctionnels capables de refl\u00e9ter l\u2019activit\u00e9 m\u00e9tabolique sous-jacente. C\u2019est l\u00e0 qu\u2019intervient la spectroscopie oculaire.<\/p>\n<h4>Ajouter une dimension fonctionnelle : la spectroscopie oculaire<\/h4>\n<p>La spectroscopie oculaire compl\u00e8te l\u2019imagerie structurelle en analysant la mani\u00e8re dont la lumi\u00e8re interagit avec le tissu pour r\u00e9v\u00e9ler sa composition biochimique. Tout comme les astronomes d\u00e9duisent la composition des \u00e9toiles \u00e0 partir de leur lumi\u00e8re, la spectroscopie oculaire mesure la lumi\u00e8re r\u00e9fl\u00e9chie par l\u2019\u0153il et identifie des motifs d\u2019absorption caract\u00e9ristiques de mol\u00e9cules sp\u00e9cifiques.<\/p>\n<p>La signature spectrale obtenue agit comme une v\u00e9ritable empreinte mol\u00e9culaire, r\u00e9v\u00e9lant la proportion d\u2019h\u00e9moglobine oxyg\u00e9n\u00e9e et d\u00e9soxyg\u00e9n\u00e9e. Elle permet ainsi de quantifier la saturation en oxyg\u00e8ne dans les tissus oculaires et d\u2019offrir un aper\u00e7u pr\u00e9coce des d\u00e9s\u00e9quilibres m\u00e9taboliques.(16) Cette approche technologique ouvre \u00e9galement la voie \u00e0 la mesure de nombreux autres biomarqueurs.<\/p>\n<p>Des chercheurs \u00e9tudient \u00e9galement le potentiel de la spectroscopie oculaire pour d\u00e9tecter l\u2019amylose \u00e0 transthyr\u00e9tine, une maladie syst\u00e9mique sous-diagnostiqu\u00e9e pouvant mener \u00e0 l\u2019insuffisance cardiaque.(17) La possibilit\u00e9 d\u2019identifier ces marqueurs mol\u00e9culaires de fa\u00e7on non invasive \u00e0 travers l\u2019\u0153il illustre toute la promesse de cette approche fonctionnelle dans la d\u00e9tection des maladies syst\u00e9miques.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.19.0&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bbrgba(135,210,150,0.26)\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb30px||30px||false|false\u00a0\u00bb border_color_all=\u00a0\u00bb#87d296&Prime; global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb|20px||20px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb|20px||20px|false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbMontserrat Regular|500|||||||\u00a0\u00bb text_line_height=\u00a0\u00bb1.25em\u00a0\u00bb quote_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb quote_text_align=\u00a0\u00bbleft\u00a0\u00bb quote_font_size=\u00a0\u00bb2rem\u00a0\u00bb quote_line_height=\u00a0\u00bb1.4em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb\u00a0\u00bb text_line_height_phone=\u00a0\u00bb1.28em\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb quote_font_size_tablet=\u00a0\u00bb1.5rem\u00a0\u00bb quote_font_size_phone=\u00a0\u00bb1.4rem\u00a0\u00bb quote_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb quote_line_height_tablet=\u00a0\u00bb\u00a0\u00bb quote_line_height_phone=\u00a0\u00bb\u00a0\u00bb quote_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<blockquote><p> L\u2019\u0153il offre un moyen sensible et non invasif de surveiller la sant\u00e9 vasculaire syst\u00e9mique et de pr\u00e9dire les issues cardiovasculaires.<\/p><\/blockquote>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text ul_item_indent=\u00a0\u00bb50px\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb2em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb max_width_tablet=\u00a0\u00bb\u00a0\u00bb max_width_phone=\u00a0\u00bb\u00a0\u00bb max_width_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb header_4_line_height_tablet=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_phone=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<h3>Des biomarqueurs r\u00e9tiniens aux r\u00e9sultats cliniques<\/h3>\n<p>Un nombre croissant d\u2019\u00e9tudes d\u00e9montrent que les signes r\u00e9tiniens refl\u00e8tent la gravit\u00e9 et le risque des maladies cardiovasculaires:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Hypertension<\/strong>: r\u00e9tr\u00e9cissement des art\u00e9rioles, pincement art\u00e9rio-veineux et r\u00e9duction de la densit\u00e9 vasculaire en OCT-A.(18)<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Ath\u00e9roscl\u00e9rose et maladie coronarienne<\/strong> : veinules dilat\u00e9es, exsudats cotonneux et d\u00e9p\u00f4ts drus\u00e9no\u00efdes sous-r\u00e9tiniens corr\u00e9l\u00e9s \u00e0 la maladie coronarienne et \u00e0 l\u2019infarctus du myocarde.<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>AVC:<\/strong> l\u2019occlusion de l\u2019art\u00e8re r\u00e9tinienne est d\u00e9sormais reconnue par l\u2019American Heart Association comme un \u00e9quivalent d\u2019AVC isch\u00e9mique, n\u00e9cessitant une \u00e9valuation cardiovasculaire urgente.(19) Des caract\u00e9ristiques suppl\u00e9mentaires, telles que des h\u00e9morragies r\u00e9tiniennes et des RIPL, correspondent \u00e9galement \u00e0 un risque accru d&rsquo;AVC.<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>Insuffisance cardiaque<\/strong>: des veinules plus larges pr\u00e9disent un risque accru d\u2019insuffisance cardiaque, associ\u00e9 \u00e0 des taux de r\u00e9admission et de mortalit\u00e9 plus \u00e9lev\u00e9s. Les analyses OCT-A r\u00e9v\u00e8lent souvent une densit\u00e9 capillaire r\u00e9duite chez ces patients.(20)<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ensemble, ces observations confirment que l\u2019\u0153il offre un moyen sensible et non invasif de surveiller la sant\u00e9 vasculaire syst\u00e9mique et de pr\u00e9dire les issues cardiovasculaires.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb link_font=\u00a0\u00bbMontserrat Regular||||||||\u00a0\u00bb link_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb2em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb max_width_tablet=\u00a0\u00bb\u00a0\u00bb max_width_phone=\u00a0\u00bb\u00a0\u00bb max_width_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb1em||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb header_4_line_height_tablet=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_phone=\u00a0\u00bb2em\u00a0\u00bb header_4_line_height_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<h3>La voie \u00e0 suivre : IA et collaboration interdisciplinaire<\/h3>\n<p>L\u2019int\u00e9gration de l\u2019analyse r\u00e9tinienne en cardiologie offre un potentiel immense, mais s\u2019accompagne de d\u00e9fis : normalisation, validation et coop\u00e9ration entre disciplines.<\/p>\n<p>L\u2019IA acc\u00e9l\u00e8re les d\u00e9couvertes en identifiant des motifs vasculaires trop subtils pour l\u2019\u0153il humain. Les mod\u00e8les d\u2019apprentissage profond peuvent estimer l\u2019\u00e2ge, la tension art\u00e9rielle ou m\u00eame le statut tabagique \u00e0 partir de simples images du fond d\u2019\u0153il.(21) Cependant, leur fiabilit\u00e9 d\u00e9pend de protocoles d\u2019imagerie uniformes et de bases de donn\u00e9es diversifi\u00e9es et bien valid\u00e9es.<\/p>\n<p>La transparence des mod\u00e8les demeure un obstacle : bien qu\u2019ils pr\u00e9disent souvent avec pr\u00e9cision, ils peinent \u00e0 expliquer leur raisonnement, freinant leur adoption clinique. De plus, la pr\u00e9sence de maladies oculaires coexistantes complique encore les algorithmes, d\u2019o\u00f9 la n\u00e9cessit\u00e9 d\u2019une curation rigoureuse des donn\u00e9es.<\/p>\n<p>Le v\u00e9ritable progr\u00e8s viendra d\u2019une collaboration \u00e9troite entre professionels de la vue, cardiologues et sp\u00e9cialistes des donn\u00e9es. Ensemble, ils peuvent combiner imagerie structurelle, analyse du flux et spectroscopie fonctionnelle pour offrir une vision compl\u00e8te de la sant\u00e9 vasculaire et m\u00e9tabolique.<\/p>\n<h3>Conclusion: red\u00e9finir la sant\u00e9 syst\u00e9mique \u00e0 travers l\u2019\u0153il<\/h3>\n<p>L\u2019\u0153il est bien plus qu\u2019un organe sensoriel : c\u2019est un reflet vivant de l\u2019\u00e9quilibre vasculaire et m\u00e9tabolique. Gr\u00e2ce \u00e0 ses structures transparentes et \u00e0 sa microvascularisation facilement observable, il se pr\u00eate id\u00e9alement \u00e0 l\u2019exploration non invasive de la sant\u00e9 syst\u00e9mique.<\/p>\n<p>La convergence de l\u2019imagerie avanc\u00e9e et de la spectroscopie oculaire marque une transition vers une \u00e9valuation personnalis\u00e9e et en temps r\u00e9el de la sant\u00e9 microvasculaire. Avec le renforcement des collaborations interdisciplinaires, l\u2019examen de la vue de routine pourrait bient\u00f4t devenir un pilier de la cardiologie pr\u00e9ventive. En fin de compte, en regardant dans l\u2019\u0153il, nous pourrions obtenir la vue la plus claire \u00e0 ce jour du c\u0153ur.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb\u00a0\u00bb width_phone=\u00a0\u00bb90%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_margin=\u00a0\u00bb3em||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_divider color=\u00a0\u00bb#87d296&Prime; divider_weight=\u00a0\u00bb1px\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb3em||0px||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb3em||0px||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb3em||0px||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_divider][et_pb_text _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.6em\u00a0\u00bb ol_font_size=\u00a0\u00bb13px\u00a0\u00bb header_3_font=\u00a0\u00bbMontserrat|500|||||||\u00a0\u00bb header_3_text_color=\u00a0\u00bb#5a5a5a\u00a0\u00bb header_3_font_size=\u00a0\u00bb1.6rem\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.6em\u00a0\u00bb header_4_font=\u00a0\u00bbMontserrat|600|||on||||\u00a0\u00bb header_4_text_color=\u00a0\u00bb#5A5A5A\u00a0\u00bb header_4_line_height=\u00a0\u00bb1.6em\u00a0\u00bb max_width=\u00a0\u00bb782px\u00a0\u00bb max_width_tablet=\u00a0\u00bb\u00a0\u00bb max_width_phone=\u00a0\u00bb\u00a0\u00bb max_width_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0vh||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1.06rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1.06rem\u00a0\u00bb header_3_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_3_font_size_phone=\u00a0\u00bb\u00a0\u00bb header_3_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_top=\u00a0\u00bb#cccccc\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3>R\u00e9f\u00e9rences<\/h3>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Jin K, Zhang J, Grzybowski A.<\/b><span style=\"font-weight: 400;\"> Editorial: Predictive and diagnostic approaches for systemic disorders using ocular assessment. <\/span><i><span style=\"font-weight: 400;\">Front Med (Lausanne).<\/span><\/i><span style=\"font-weight: 400;\"> 2024;11:1529861. Published 2024 Dec 11. doi:10.3389\/fmed.2024.1529861<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Kellner RL, Harris A, Ciulla L, et al.<\/b><span style=\"font-weight: 400;\"> The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease. <\/span><i><span style=\"font-weight: 400;\">J Clin Med.<\/span><\/i><span style=\"font-weight: 400;\"> 2024;13(3):829. Published 2024 Jan 31. doi:10.3390\/jcm13030829<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bisen JB, Sikora H, Aneja A, Shah SJ, Mirza RG.<\/b><span style=\"font-weight: 400;\"> Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine. <\/span><i><span style=\"font-weight: 400;\">J Cardiovasc Dev Dis.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;12(6):230. doi:10.3390\/jcdd12060230<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Meira Fogel-Levin S, Sadda SR, Rosenfeld PJ, et al.<\/b><span style=\"font-weight: 400;\"> Advanced retinal imaging and applications for clinical practice: A consensus review. <\/span><i><span style=\"font-weight: 400;\">Surv Ophthalmol.<\/span><\/i><span style=\"font-weight: 400;\"> 2022;67(5):1049-1078. doi:10.1016\/j.survophthal.2022.02.005<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lee SJV, Goh YQ, Rojas-Carabali W, et al.<\/b><span style=\"font-weight: 400;\"> Association between retinal vessels caliber and systemic health: A comprehensive review. <\/span><i><span style=\"font-weight: 400;\">Surv Ophthalmol.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;70(2):184-199. doi:10.1016\/j.survophthal.2024.11.009<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Egle M, Hamedani AG, Deal JA, et al.<\/b><span style=\"font-weight: 400;\"> Retinal microstructure and microvasculature in association with brain amyloid burden. <\/span><i><span style=\"font-weight: 400;\">Brain Commun.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;7(1):fcaf013. doi:10.1093\/braincomms\/fcaf013<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Flammer J, Konieczka K, Bruno RM, et al.<\/b><span style=\"font-weight: 400;\"> The eye and the heart. <\/span><i><span style=\"font-weight: 400;\">Eur Heart J.<\/span><\/i><span style=\"font-weight: 400;\"> 2013;34(17):1270-1278. doi:10.1093\/eurheartj\/eht023<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lim LS, Tan B, Ong YT, et al.<\/b><span style=\"font-weight: 400;\"> Longitudinal evaluation of cotton wool spot following rapid glycemic control. <\/span><i><span style=\"font-weight: 400;\">Am J Ophthalmol Case Rep.<\/span><\/i><span style=\"font-weight: 400;\"> 2024;33:102255. doi:10.1016\/j.ajoc.2024.102255<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Zhou S, Yan Q, Guo J, He W, Zhao Y.<\/b><span style=\"font-weight: 400;\"> Early diagnosis of coronary heart disease based on retinal microvascular parameters of OCTA. <\/span><i><span style=\"font-weight: 400;\">Front Cell Dev Biol.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;13:1654159. Published 2025 Aug 12. doi:10.3389\/fcell.2025.1654159<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Poirier J, Allain G, Bansept MA, et al.<\/b><span style=\"font-weight: 400;\"> Standardizing image acquisition and processing methods: A critical need for the accurate assessment of retinal blood vessel tortuosity. <\/span><i><span style=\"font-weight: 400;\">Biomed Opt Express.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;16(4):2739-2755. doi:10.1364\/BOE.516004<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ekhator C, Devi M, Barker C, et al.<\/b><span style=\"font-weight: 400;\"> Arterial Tortuosity Syndrome: Unraveling a Rare Vascular Disorder. <\/span><i><span style=\"font-weight: 400;\">Cureus.<\/span><\/i><span style=\"font-weight: 400;\"> 2023;15(9):e44906. doi:10.7759\/cureus.44906<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tripathy K, Modi P, Arsiwalla T.<\/b><span style=\"font-weight: 400;\"> Hypertensive Retinopathy. In: <\/span><i><span style=\"font-weight: 400;\">StatPearls<\/span><\/i><span style=\"font-weight: 400;\"> [Internet]. Treasure Island, FL: StatPearls Publishing; July 6, 2025. Available from:<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525980\/\"> <span style=\"font-weight: 400;\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525980\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bellanda V, Delaney A, Schulgit MJ, et al.<\/b><span style=\"font-weight: 400;\"> Screening for Retinal Ischemic Perivascular Lesions in Patients Undergoing Cardiovascular Assessment: A Cross-Sectional Study. <\/span><i><span style=\"font-weight: 400;\">Ophthalmol Retina.<\/span><\/i><span style=\"font-weight: 400;\"> Published online 2025 Sep 9. doi:10.1016\/j.oret.2025.09.002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Madala S, Adabifirouzjaei F, Lando L, et al.<\/b><span style=\"font-weight: 400;\"> Retinal Ischemic Perivascular Lesions, a Biomarker of Cardiovascular Disease. <\/span><i><span style=\"font-weight: 400;\">Ophthalmol Retina.<\/span><\/i><span style=\"font-weight: 400;\"> 2022;6(9):865-867. doi:10.1016\/j.oret.2022.05.005<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Untracht GR, Matos R, Dikaios N, et al.<\/b><span style=\"font-weight: 400;\"> OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images. <\/span><i><span style=\"font-weight: 400;\">arXiv.<\/span><\/i><span style=\"font-weight: 400;\"> 2021. Available from:<\/span><a href=\"https:\/\/arxiv.org\/abs\/2109.01835\"> <span style=\"font-weight: 400;\">https:\/\/arxiv.org\/abs\/2109.01835<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lapointe N, Akitegetse C, Poirier J, et al.<\/b><span style=\"font-weight: 400;\"> Targeted Spectroscopy in the Eye Fundus. <\/span><i><span style=\"font-weight: 400;\">J Biomed Opt.<\/span><\/i><span style=\"font-weight: 400;\"> 2023;28(12):126004. doi:10.1117\/1.JBO.28.12.126004<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Zilia Inc.<\/b><span style=\"font-weight: 400;\"> Zilia launches innovative project to detect a rare heart disease. <\/span><i><span style=\"font-weight: 400;\">Zilia Blog.<\/span><\/i><span style=\"font-weight: 400;\"> Published 2024 May 15. Available from:<\/span><a href=\"https:\/\/ziliahealth.com\/blog\/ocular-spectroscopy-attr-amyloidosis-detection\"> <span style=\"font-weight: 400;\">https:\/\/ziliahealth.com\/blog\/ocular-spectroscopy-attr-amyloidosis-detection<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lee WH, Park JH, Won Y, et al.<\/b><span style=\"font-weight: 400;\"> Retinal microvascular change in hypertension as measured by optical coherence tomography angiography. <\/span><i><span style=\"font-weight: 400;\">Sci Rep.<\/span><\/i><span style=\"font-weight: 400;\"> 2019;9(1):156. doi:10.1038\/s41598-018-36474-1<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mac Grory B, Schrag M, Biousse V, et al.<\/b><span style=\"font-weight: 400;\"> Management of Central Retinal Artery Occlusion: A Scientific Statement From the American Heart Association. <\/span><i><span style=\"font-weight: 400;\">Stroke.<\/span><\/i><span style=\"font-weight: 400;\"> 2021;52(6):e282-e294. doi:10.1161\/STR.0000000000000366<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bayat K, Pooyan P, Chhablani J, et al.<\/b><span style=\"font-weight: 400;\"> Retinal and Choroidal Alterations in Heart Failure: A Systematic Review and Meta-analysis of OCT and OCT-A Findings with Emphasis on HFrEF. <\/span><i><span style=\"font-weight: 400;\">Ophthalmol Ther.<\/span><\/i><span style=\"font-weight: 400;\"> 2025;14(11):2631-2651. doi:10.1007\/s40123-025-01238-4<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Poplin R, Varadarajan AV, Blumer K, et al.<\/b><span> Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. <\/span>Nat Biomed Eng.2018;2(3):158-164. doi:10.1038\/s41551-018-0195-0<\/li>\n<\/ol>\n<p>[\/et_pb_text][et_pb_divider color=\u00a0\u00bb#87d296&Prime; 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_builder_version=\u00a0\u00bb4.16&Prime; custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.17.4&Prime; text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb]<\/p>\n<p>\u00c0 propos<\/p>\n<p>[\/et_pb_text][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.21.2&Prime; text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<a href=\"https:\/\/ziliahealth.com\/fr\/a-propos\/\">Histoire<\/a><br \/>\n<a href=\"https:\/\/ziliahealth.com\/fr\/a-propos\/equipe\/\">\u00c9quipe<\/a><br \/>\n<a href=\"https:\/\/ziliahealth.com\/fr\/blogue\/\">Blogue<br \/><\/a><a href=\"https:\/\/ziliahealth.com\/fr\/nouvelles\/\">Nouvelles<\/a><br \/><a href=\"https:\/\/ziliahealth.com\/fr\/carrieres\/\">Carri\u00e8res<\/a><br \/><a href=\"https:\/\/ziliahealth.com\/fr\/evenements\/\">\u00c9v\u00e8nements<br \/><\/a><a href=\"https:\/\/ziliahealth.com\/fr\/contact\/\">Contactez-nous<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_5&Prime; _builder_version=\u00a0\u00bb4.16&Prime; global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p>Solutions<\/p>\n<p>[\/et_pb_text][et_pb_text content_phone=\u00a0\u00bb<\/p>\n<p><a href=%22https:\/\/ziliahealth.com\/solution\/%22>Technology<\/a><br \/> <a href=%22https:\/\/ziliahealth.com\/zilia-ocular\/%22>Zilia Ocular<br \/><\/a><a href=%22https:\/\/ziliahealth.com\/vision-loss\/%22>Vision Loss<\/a><\/p>\n<p>\u00a0\u00bb content_last_edited=\u00a0\u00bboff|desktop\u00a0\u00bb disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p><a href=\"https:\/\/ziliahealth.com\/fr\/solution\/\">Technologie<\/a><br \/> <a href=\"https:\/\/ziliahealth.com\/fr\/zilia-ocular\/\">Zilia Ocular<br \/><\/a><a href=\"https:\/\/ziliahealth.com\/fr\/soins-oculaires\/\">Soins oculaires<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_5&Prime; _builder_version=\u00a0\u00bb4.16&Prime; global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]L\u00e9gal[\/et_pb_text][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p><a href=\"https:\/\/ziliahealth.com\/fr\/cookies\/\">Cookies<\/a><br \/> <a href=\"https:\/\/ziliahealth.com\/fr\/confidentialite\/\">Confidentialit\u00e9<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_5&Prime; _builder_version=\u00a0\u00bb4.16&Prime; global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; text_font=\u00a0\u00bbMontserrat||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb1.1rem\u00a0\u00bb text_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_margin=\u00a0\u00bb||8px|\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb1rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb1rem\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]Certifications[\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/ziliahealth.com\/wp-content\/uploads\/2019\/11\/Thumb_mark-of-trust-certified-ISO-13485-quality-management-for-medical-devices-black-logo-En-GB-1019.jpg\u00a0\u00bb title_text=\u00a0\u00bbThumb_mark-of-trust-certified-ISO-13485-quality-management-for-medical-devices-black-logo-En-GB-1019&Prime; 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_module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb module_alignment=\u00a0\u00bbleft\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb\u00a0\u00bb custom_padding_phone=\u00a0\u00bb10px||||false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb link_option_url=\u00a0\u00bbhttp:\/\/ziliahealth.com\/fr\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbcenter\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb]<\/p>\n<p><a href=\"https:\/\/ziliahealth.com\/fr\/\">EN<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_css_main_element=\u00a0\u00bbmargin:auto\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text content_tablet=\u00a0\u00bb<\/p>\n<p style=%22text-align: center;%22>Zilia Inc. \u00a9 2023<\/p>\n<p>\u00a0\u00bb content_phone=\u00a0\u00bb<\/p>\n<p style=%22text-align: center;%22>Zilia Inc. \u00a9 2023<\/p>\n<p>\u00a0\u00bb content_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb module_class=\u00a0\u00bbcopyright\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font_size=\u00a0\u00bb0.9rem\u00a0\u00bb text_line_height=\u00a0\u00bb2.5em\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_phone=\u00a0\u00bb0.8rem\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb]<\/p>\n<p style=\"text-align: center;\">Zilia Inc. \u00a9 2025<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; 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