Comparing Standard Treatments in Real-World Practice

Led by Dr. Shaheer Aboobaker, Managing Partner and Co-Director of Clinical Research at TRI, ThRIVE will enroll newly diagnosed patients beginning treatment and follow them over two years. The study aims to generate long-term, real-world evidence on how each therapy preserves vision, how frequently injections are required, and how well retinal stability is maintained over time.

Although both treatments are approved and widely used across Canada, head-to-head long-term data outside of controlled clinical trials remains limited. ThRIVE is designed to close that gap.

“This study will give us a clearer picture of how these treatments perform in everyday clinical practice,” said Dr. Aboobaker. “The findings could meaningfully shape treatment decisions for patients with AMD and DME for years to come.”

Measuring Retinal Oxygen with Zilia Ocular

As part of the study, retinal oxygen saturation will be measured using the Zilia Ocular — a non-invasive imaging device that captures oxygen levels in retinal tissue. These measurements will offer novel insight into how the eye responds to each treatment at a physiological level, complementing traditional visual and anatomical assessments.
“We’re proud that the Zilia Ocular is part of this important research,” said Dr. Patrick Sauvageau, OD, CEO and Co-founder of Zilia. “By contributing objective oxygenation biomarkers to the ThRIVE study, we hope to deepen our understanding of treatment response at the tissue level — opening the door to more informed and personalized care.”

About Zilia

Zilia is a health technology company developing a groundbreaking platform to non-invasively measure biomarkers in the eye, with an initial focus on ocular oximetry. By integrating advanced photonics and artificial intelligence, Zilia’s first-of-kind technology is intended to leverage the eye’s optical properties and its direct connections to the vascular system and the brain, capturing critical information on ocular and overall health.

For Further Information

Zilia: https://ziliahealth.com/